Trifluoroacetic acid → HCID 10194678, compound

Participants

Reaction Steps

N-{(1R,2R)-1-[(tert-Butoxycarbonylmethyl) amino]-2,3-dihydro-1H-inden-2-yl}-2,3-dichloro-4H-thieno[3,2-b]pyrrole-5-carboxamide (Example 29; 100 mg, 0.21 mmol) dissolved in DCM (10 mL). TFA (1 mL) added and the reaction stirred at ambient temperature for 6 hours. Evaporation under reduced pressure, co-evaporation with CHCI3 (2×10 mL) and drying gave the title compound (85 mg, 36%) as a white powder.

Provenance & Evidence