Trifluoroacetic acid → HCID 10194678, compound

HRID 1244713Notes

Reaction equation

HRID 1244713 reaction equation
C([O:5][C:6]([CH2:8][NH:9][C@@H:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][C@H:11]1[NH:19][C:20]([C:22]1[NH:26][C:25]2[C:27]([Cl:31])=[C:28]([Cl:30])[S:29][C:24]=2[CH:23]=1)=[O:21])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:6]([CH2:8][NH:9][C@@H:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][C@H:11]1[NH:19][C:20]([C:22]1[NH:26][C:25]2[C:27]([Cl:31])=[C:28]([Cl:30])[S:29][C:24]=2[CH:23]=1)=[O:21])([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 10195618HCID 10195618, compound

Product 1

HCID 10194678HCID 10194678, compoundYield 95.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-{(1R,2R)-1-[(tert-Butoxycarbonylmethyl) amino]-2,3-dihydro-1H-inden-2-yl}-2,3-dichloro-4H-thieno[3,2-b]pyrrole-5-carboxamide (Example 29; 100 mg, 0.21 mmol) dissolved in DCM (10 mL). TFA (1 mL) added and the reaction stirred at ambient temperature for 6 hours. Evaporation under reduced pressure, co-evaporation with CHCI3 (2×10 mL) and drying gave the title compound (85 mg, 36%) as a white powder.

Workup

  1. customEvaporation under reduced pressure, co-evaporation with CHCI3 (2×10 mL)
  2. customdrying

Sources & evidence

ORD record
ord-d2a4a3e5b8a740238a18d04d5f66e880
Source dataset
uspto-grants-2006_10
Patent number
US07122567B2

Reaction notes

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