Dichloromethane → HCID 10127775, compound

HRID 1244714Notes

Reaction equation

HRID 1244714 reaction equation
[C:1]([OH:7])([C:3](F)(F)F)=[O:2].[Cl:8][C:9]1[S:16][C:15]2[CH:14]=[C:13]([C:17]([NH:19][C@H:20]3[CH2:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[C@@H:21]3[NH:29][C:30](N3CCN(C)CC3)=[O:31])=[O:18])[NH:12][C:11]=2[C:10]=1[Cl:39].[CH2:40](Cl)Cl>>[C:30]([N:29]([C@@H:21]1[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:28][C@H:20]1[NH:19][C:17]([C:13]1[NH:12][C:11]2[C:10]([Cl:39])=[C:9]([Cl:8])[S:16][C:15]=2[CH:14]=1)=[O:18])[CH2:3][C:1]([OH:7])=[O:2])(=[O:31])[CH3:40]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 10289049HCID 10289049, compound

Product 1

HCID 10127775HCID 10127775, compoundYield 94%

Procedure

TFA (1 mL) was added to a solution of 1,1-dimethylethyl [acetyl((1R,2R)-2-{[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino}-2,3-dihydro-1H-inden-1-yl)amino]acetate (Method 18, 40 mg, 0.08 mmol) in DCM (5 mL) and the reaction was stirred at ambient temperature for 1 h. The volatiles were removed by evaporation under reduced pressure to afford the title compound (35 mg, 94%) as a white solid.

Workup

  1. customThe volatiles were removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-a1777c8da9d0403791deb6ba0ad219a5
Source dataset
uspto-grants-2006_10
Patent number
US07122567B2

Reaction notes

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