Trifluoroacetic acid → HCID 69545861, compound

HRID 1244732Notes

Reaction equation

HRID 1244732 reaction equation
C(O)(C(F)(F)F)=O.[C:8]([O:11][CH2:12][C:13]([N:15]([CH2:38][C:39]([O:41]C(C)(C)C)=[O:40])[C@@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][C@H:17]1[NH:25][C:26]([C:28]1[NH:32][C:31]2[C:33]([Cl:37])=[C:34]([Cl:36])[S:35][C:30]=2[CH:29]=1)=[O:27])=[O:14])(=[O:10])[CH3:9]>C(Cl)Cl>[C:8]([O:11][CH2:12][C:13]([N:15]([CH2:38][C:39]([OH:41])=[O:40])[C@@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][C@H:17]1[NH:25][C:26]([C:28]1[NH:32][C:31]2[C:33]([Cl:37])=[C:34]([Cl:36])[S:35][C:30]=2[CH:29]=1)=[O:27])=[O:14])(=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86598707HCID 86598707, compound

Product 1

HCID 69545861HCID 69545861, compoundYield 99.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (3 mL) was added to a solution of 1,1-dimethylethyl [[(acetyloxy)acetyl]((1R,2R)-2-{[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino}-2,3-dihydro-1H-inden-1-yl)amino]acetate (Method 20, 130 mg, 0.25 mmol) in DCM (10 mL) and the reaction was stirred at ambient temperature for 2 h. The volatiles were removed by evaporation under reduced pressure to afford the title compound (130 mg, 99%) as a white solid.

Workup

  1. customThe volatiles were removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-2711270daa354c04bcaf4559e2242394
Source dataset
uspto-grants-2006_10
Patent number
US07122567B2

Reaction notes

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