Hydrogen Peroxide → HCID 21920299, compound

HRID 1244774Notes

Reaction equation

HRID 1244774 reaction equation
[CH:1]1([N:7]=[C:8]2[S:12][C:11]([C:13]3[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=3)=[N:10][N:9]2[CH3:21])[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1.C([O-])([O-])=[O:23].[Na+].[Na+].OO>C(O)C.O>[CH:1]1([N:7]=[C:8]2[S:12][C:11]([C:13]3[CH:14]=[CH:15][C:16]([C:17]([NH2:18])=[O:23])=[CH:19][CH:20]=3)=[N:10][N:9]2[CH3:21])[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1

Participants

6

Reactant 3

HCID 784Hydrogen PeroxideHCID 10340Sodium CarbonateHCID 21920198HCID 21920198, compound

Product 1

HCID 21920299HCID 21920299, compoundYield 64%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 4-[5-(cyclohex-3-enylimino)-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl]-benzonitrile from protocol I76 (0.94 mmol, 280 mg) in ethanol (41 mL), a solution of Na2CO3 [3N] (12.3 mmol, 4.1 mL), and a solution of H2O2 at 30% in water (3.33 mL) were added. The mixture was stirred overnight at RT and concentrated under reduced pressure. The residue was stirred in water several hours, filtered, and dried under vacuum to afford the pure product. Yield: 64%.

Workup

  1. concentrationconcentrated under reduced pressure
  2. stirringThe residue was stirred in water several hours
  3. filtrationfiltered
  4. customdried under vacuum
  5. customto afford the pure product

Sources & evidence

ORD record
ord-7a68a94c28f141e8aa785548d06bd26d
Source dataset
uspto-grants-2006_10
Patent number
US07122565B2

Reaction notes

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