2-bromo-N-(4-methylpent-2-yn-4-yl)butyramide → 2-(3,8-dibromo-6-quinolinyloxy)-N-(4-methylpent-2-yn-4-yl) butyramide

HRID 1244814Notes

Reaction equation

HRID 1244814 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([OH:12])=[CH:7][C:6]=2[Br:13].Br[CH:15]([CH2:25][CH3:26])[C:16]([NH:18][C:19]([CH3:24])([CH3:23])[C:20]#[C:21][CH3:22])=[O:17]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([O:12][CH:15]([CH2:25][CH3:26])[C:16]([NH:18][C:19]([CH3:24])([CH3:23])[C:20]#[C:21][CH3:22])=[O:17])=[CH:7][C:6]=2[Br:13]

Participants

3

Reactant 2

HCID 210784062-bromo-N-(4-methylpent-2-yn-4-yl)butyramideHCID 219231363,8-Dibromo-6-hydroxyquinoline

Product 1

HCID 692538862-(3,8-dibromo-6-quinolinyloxy)-N-(4-methylpent-2-yn-4-yl) butyramide

Procedure

In a similar procedure, 3,8-dibromo-6-hydroxyquinoline was reacted with 2-bromo-N-(4-methylpent-2-yn-4-yl) butyramide to give 2-(3,8-dibromo-6-quinolinyloxy)-N-(4-methylpent-2-yn-4-yl) butyramide as a colourless gum, 1H NMR (CDCl3) δ: 1.07(3H, t); 1.59 (3H, s); 1.60(3H, s); 1.78(3H, s); 1.99–2.06(2H, m); 4.52(1H, t); 6.30(1H, s); 7.00(1H, m); 7.82(1H, dd); 8.21(1H, d); 8.88(1H, m).

Sources & evidence

ORD record
ord-7b32c218b2df4edca33614b9f20c263d
Source dataset
uspto-grants-2006_10
Patent number
US07122672B2

Reaction notes

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