HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylaniline → (+/-)-(1-Aminomethyl-3,3-dimethyl-cyclopentyl)-acetic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 21923172 | HCID 21923172 | — |
| Reactant | Glyoxylyl Chloride p-toluenesulfonylhydrazone | HCID 57296158 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (+/-)-(1-Aminomethyl-3,3-dimethyl-cyclopentyl)-acetic acid hydrochloride | HCID 69533136 | — |
Reaction Steps
In step four, the alcohol 4 is treated with glyoxylic acid chloride (p-toluenesulfonyl)hydrazone and N,N-dimethylaniline followed by triethylamine in a solvent such as methylene chloride, chloroform, benzene, or toluene to give the diazoacetate 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122678B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-73cdc15d1da94f7c8c6c8531d5f9e082 |
| Source note | uspto-grants-2006_10 |