HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl iodide → 3-Isobutyl-4-methoxy-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl iodide | HCID 10556 | — |
| Reactant | 4-Methoxy-2-indolinone | HCID 596001 | — |
| Product | 3-Isobutyl-4-methoxy-1,3-dihydro-indol-2-one | HCID 21923255 | 80% |
Reaction Steps
3-Isobutyl-4-methoxy-1,3-dihydro-indol-2-one is prepared from 4-methoxyoxindole (3.1 mmol) and 1-iodo-2-methylpropane (3.1 mmol) substantially as described above for Epoxide 1 and Epoxide 2. The compound is purified by flash chromatography (SiO2, 25% ethyl acetate:hexane) to obtain 180 mg (27%) of the desired compound. MS (ESI+) 220.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122680B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-75787fd88d294410b5d99fba4199f459 |
| Source note | uspto-grants-2006_10 |