HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 3-Benzyl-4-methoxy-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | 4-Methoxy-2-indolinone | HCID 596001 | — |
| Product | 3-Benzyl-4-methoxy-1,3-dihydro-indol-2-one | HCID 21923253 | 73% |
Reaction Steps
3-Benzyl-4-methoxy-1,3-dihydro-indol-2-one is prepared from 4-methoxyoxindole (4.8 mmol) and benzyl bromide (5.3 mmol) substantially as described above for Epoxide 4. The compound is purified by flash chromatography (SiO2, 25% ethyl acetate:hexane) to obtain the desired compound (36%). MS (ESI+) 254.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122680B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-bdc39819da3e477fa7e28ddd26541e28 |
| Source note | uspto-grants-2006_10 |