HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 21922989, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-(2-aminoethyl)-2-chloro-9-cyclopentyl-9H-purin-6-amine | HCID 21922924 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 21922989 | HCID 21922989 | 79.5% |
Reaction Steps
280 mg of the product obtained in Stage 1 of Example 7, 3 ml of methylene chloride, 0.17 ml of NEt3 (triethylamine) and 230 mg of 4-methyl-benzenesulphonic acid chloride are mixed together then the reaction medium is agitated at ambient temperature for approximately 30 minutes. Then 2 ml of water is added, followed by extracting with 2×5 ml of methylene chloride, washing with 5 ml of water, drying, evaporating, impasting in ether, separating and drying. In this way 345 mg of expected product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122669B1 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-83deab9426f144b48c1803ffcd513376 |
| Source note | uspto-grants-2006_10 |