Aniline → HCID 21923032, compound

HRID 1244917Notes

Reaction equation

HRID 1244917 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4](Cl)[N:3]=1.[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:3]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 21923063HCID 21923063, compound

Product 1

HCID 21923032HCID 21923032, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

The operation is carried out as in Stage 2 of Example 2 from 200 mg (0.77 mM) of the product obtained in Stage 1 of Example 2 and 3 ml of butanol and using 0.088 ml of aniline (0.96 mmole) in place of the benzylamine. In this way 213 mg of expected product is obtained in the form of white crystals.

Sources & evidence

ORD record
ord-6caae1a9fd254690bc611d780eb3f475
Source dataset
uspto-grants-2006_10
Patent number
US07122669B1

Reaction notes

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