Dichloromethane → HCID 21923042, compound

HRID 1244938Notes

Reaction equation

HRID 1244938 reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][C:5]1[N:13]=[C:12]([Cl:14])[N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[CH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1.C(Cl)Cl.C(N(CC)CC)C.[CH3:30][CH:31]([S:33](Cl)(=[O:35])=[O:34])[CH3:32]>O>[Cl:14][C:12]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][N:9]2[CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:5]([NH:4][CH2:3][CH2:2][NH:1][S:33]([CH:31]([CH3:32])[CH3:30])(=[O:35])=[O:34])[N:13]=1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 824082-Propanesulfonyl chlorideHCID 21922924N-(2-aminoethyl)-2-chloro-9-cyclopentyl-9H-purin-6-amine

Product 1

HCID 21923042HCID 21923042, compoundYield 29.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The operation is carried out as in Stage 1 of Example 10 starting from 280 mg of the product obtained in Stage 1 of Example 7, 4 ml of methylene chloride, 0.2 ml of triethylamine and 172 mg of 1-methylethanesulphonic acid chloride in place of the 4-methyl-benzenesulphonic acid chloride then the reaction medium is agitated at ambient temperature for approximately 30 min. Then 2 ml of water is added, followed by extracting with 3×5 ml of methylene chloride, washing with 5 ml of saturated sodium chloride, drying, evaporating, impasting in 5 ml of ether then in 5 ml of pentane, separating, and drying. After chromatography on silica eluting with methylene chloride/CH3CN in a proportion of 70/30, 115 mg of expected product is thus obtained in the form of white crystals.

Workup

  1. extractionby extracting with 3×5 ml of methylene chloride
  2. washwashing with 5 ml of saturated sodium chloride
  3. customdrying
  4. customevaporating
  5. customin 5 ml of pentane, separating
  6. customdrying

Sources & evidence

ORD record
ord-d3b6ead8e5b94f34b376f92b50b3afb9
Source dataset
uspto-grants-2006_10
Patent number
US07122669B1

Reaction notes

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