Dichloromethane → HCID 21922910, compound

HRID 1244956Notes

Reaction equation

HRID 1244956 reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][C:5]1[N:13]=[C:12]([Cl:14])[N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[CH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1.C(Cl)Cl.C(N(CC)CC)C.[Cl:30][C:31]1[CH:32]=[C:33]([CH:37]=[CH:38][C:39]=1[Cl:40])[C:34](Cl)=[O:35]>O>[Cl:14][C:12]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][N:9]2[CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:5]([NH:4][CH2:3][CH2:2][NH:1][C:34](=[O:35])[C:33]2[CH:37]=[CH:38][C:39]([Cl:40])=[C:31]([Cl:30])[CH:32]=2)[N:13]=1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 76403Benzoyl chloride, 3,4-dichloro-HCID 21922924N-(2-aminoethyl)-2-chloro-9-cyclopentyl-9H-purin-6-amine

Product 1

HCID 21922910HCID 21922910, compoundYield 52.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

280 mg of the product obtained in Stage 1 of Example 7, 4 ml of methylene chloride, 0.28 ml triethylamine and 251 mg of 3,4-dichlorobenzoyl chloride are mixed together then the reaction medium is agitated at ambient temperature for 1 hour. Then 2 ml of water is added, followed by extracting with methylene chloride, drying and evaporating the solvents. In this way 237 mg of expected product is obtained.

Workup

  1. extractionby extracting with methylene chloride
  2. customdrying
  3. customevaporating the solvents

Sources & evidence

ORD record
ord-d713446b1f504b0287eedd8ecaa7af2f
Source dataset
uspto-grants-2006_10
Patent number
US07122669B1

Reaction notes

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