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HRID1244967

反应详情

EQUATION

反应方程式

HRID 1244967 的结构方程式

REACTANTS

反应物

4
结构：O=C(O)c1cccc(C(F)(F)F)c1
HCID9963

3-(Trifluoromethyl)benzoic acid

C8H5F3O2

结构：CCN=C=NCCCN(C)C.Cl
HCID2723939

1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

C8H18ClN3

结构：O.On1nnc2ccccc21
HCID2796029

1H-Benzotriazol-1-ol--water (1/1)

C6H7N3O2

结构：NCCNc1nc(Cl)nc2c1ncn2C1CCCC1
HCID21922924

未命名化合物

PRODUCTS

生成物

1
结构：O=C(NCCNc1nc(Cl)nc2c1ncn2C1CCCC1)c1cccc(C(F)(F)F)c1
HCID21922944

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O
溶剂HCID962

Water

H2O

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

280 mg of the product obtained in Stage 1 of Example 7, 203 mg of 1-hydroxybenzotriazole hydrate, 287 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in 4 ml of dichloromethane are mixed together, 230 mg of 3-trifluoromethyl benzoic acid is added and agitation is carried out for 6 hours and 30 minutes at ambient temperature. Water is added, followed by separating, washing with ether, drying and 307 mg of expected product is collected.

WORKUP

后处理

  1. customby separating
  2. washwashing with ether
  3. customdrying
  4. custom307 mg of expected product is collected