Aluminium lithium hydride → HCID 21922672, compound

HRID 1244983Notes

Reaction equation

HRID 1244983 reaction equation
C(O[C:6]([NH:8][CH2:9][CH2:10][CH2:11][C:12]1[C:13]([C:24]2[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=2)=[C:14]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[NH:15][CH:16]=1)=O)(C)(C)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[F:23][C:20]1[CH:19]=[CH:18][C:17]([C:14]2[NH:15][CH:16]=[C:12]([CH2:11][CH2:10][CH2:9][NH:8][CH3:6])[C:13]=2[C:24]2[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=2)=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21922688HCID 21922688, compound

Product 1

HCID 21922672HCID 21922672, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

400 mg (1.01 mmol) of 4-[3-(t-butoxycarbonylamino)propyl]-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole [prepared as described in step 4(i) above] were added to a suspension of 154 mg of lithium aluminum hydride in 8 ml of tetrahydrofuran. The resulting mixture was heated under reflux for 2 hours. At the end of this time, the reaction mixture was worked up and then purified in the same manner as that described in Example 1(vi) above to give 300 mg (yield 96%) of the title compound as a white powder.

Workup

  1. temperatureThe resulting mixture was heated
  2. temperatureunder reflux for 2 hours
  3. custompurified in the same manner as

Sources & evidence

ORD record
ord-6698c2105fbc4e12857af31cac64a4c0
Source dataset
uspto-grants-2006_10
Patent number
US07122666B2

Reaction notes

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