Methylamine → HCID 21922826, compound

HRID 1245020Notes

Reaction equation

HRID 1245020 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][CH:10]=[CH:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[C:15](S(C)(=O)=O)[N:14]=2)=[CH:4][CH:3]=1.[CH3:23][NH2:24]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][CH:10]=[CH:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH:24][CH3:23])[N:14]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 21922748HCID 21922748, compound

Product 1

HCID 21922826HCID 21922826, compound

Procedure

In a similar manner to that described in Example 42(iii) above, 2-(4-fluorophenyl)-3-(2-methanesulfonylpyrimidin-4-yl)-1H-pyrrole [prepared as described in step 1(ii) above] was reacted with methylamine to afford the title compound (quantitative yield) as a pale brown amorphous solid.

Sources & evidence

ORD record
ord-ebef1101af294cd194650ee1380ccfaa
Source dataset
uspto-grants-2006_10
Patent number
US07122666B2

Reaction notes

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