Triisopropylsilyl trifluoromethanesulfonate → HCID 21922703, compound

HRID 1245021Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][CH:10]=[CH:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH3:20])[N:14]=2)=[CH:4][CH:3]=1.O([Si:29]([CH:36]([CH3:38])[CH3:37])([CH:33]([CH3:35])[CH3:34])[CH:30]([CH3:32])[CH3:31])S(C(F)(F)F)(=O)=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]([Si:29]([CH:36]([CH3:38])[CH3:37])([CH:33]([CH3:35])[CH3:34])[CH:30]([CH3:32])[CH3:31])[CH:10]=[CH:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH3:20])[N:14]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 2724529Triisopropylsilyl trifluoromethanesulfonate

HCID 21922826HCID 21922826, compound

Product 1

HCID 21922703HCID 21922703, compoundYield 82%

Procedure

In a similar manner to that described in Example 7(ii) above, 2-(4-fluorophenyl)-3-(2-methylaminopyrimidin-4-yl)-1H-pyrrole [prepared as described in step 1(iii) above] was reacted with triisopropylsilyl triflate, to afford the title compound (yield 82%) as a white powder.

Sources & evidence

ORD record: ord-f208e99945624944987af7ff5a0f72f5
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07122666B2

Reaction notes

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