Pyrrolidine → HCID 57501858, compound

Participants

Reaction Conditions

Reaction Steps

2.62 ml (31.4 mmol) of pyrrolidine were added to a solution of 2.62 g (15.7 mmol) of (8aS)-8-methyl-1,2,3,5,6,7,8,8a-octahydroindolizine-5,7-dione [obtained as described in Preparative Example 9(iii)′ above] in 30 ml of ethanol and the resulting mixture was stirred for 30 minutes at 80° C. After the reaction was completed, the solvent and excess pyrrolidine were removed from the reaction mixture by evaporation under reduced pressure to afford 3.67 g (yield: quantitative) of the title compound as a brown oil.

Provenance & Evidence