Pyrrolidine → HCID 57501858, compound

HRID 1245037Notes

Reaction equation

HRID 1245037 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:6][CH:7]1[C@H:15]2[N:11]([CH2:12][CH2:13][CH2:14]2)[C:10](=[O:16])[CH2:9][C:8]1=O>C(O)C>[CH3:6][CH:7]1[C@H:15]2[N:11]([CH2:12][CH2:13][CH2:14]2)[C:10](=[O:16])[CH:9]=[C:8]1[N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 57457970HCID 57457970, compound

Product 1

HCID 57501858HCID 57501858, compoundYield 106.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

2.62 ml (31.4 mmol) of pyrrolidine were added to a solution of 2.62 g (15.7 mmol) of (8aS)-8-methyl-1,2,3,5,6,7,8,8a-octahydroindolizine-5,7-dione [obtained as described in Preparative Example 9(iii)′ above] in 30 ml of ethanol and the resulting mixture was stirred for 30 minutes at 80° C. After the reaction was completed, the solvent and excess pyrrolidine were removed from the reaction mixture by evaporation under reduced pressure to afford 3.67 g (yield: quantitative) of the title compound as a brown oil.

Workup

  1. customobtained
  2. customthe solvent and excess pyrrolidine were removed from the reaction mixture by evaporation under reduced pressure

Sources & evidence

ORD record
ord-72c48dd123f943288a027bc69249cf54
Source dataset
uspto-grants-2006_10
Patent number
US07122666B2

Reaction notes

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