Pyrrolidine → HCID 57501860, compound

HRID 1245040Notes

Reaction equation

HRID 1245040 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:6][O:7][C@@H:8]1[CH2:16][N:15]2[C@H:10]([CH2:11][C:12](=O)[CH2:13][C:14]2=[O:17])[CH2:9]1>C(O)C>[CH3:6][O:7][C@@H:8]1[CH2:16][N:15]2[C@@H:10]([CH2:11][C:12]([N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)=[CH:13][C:14]2=[O:17])[CH2:9]1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 45091337HCID 45091337, compound

Product 1

HCID 57501860HCID 57501860, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.07 ml (36.8 mmol) of pyrrolidine were added to a solution of 3.38 g (18.4 mmol) of (2S,8aS)-2-methoxy-1,2,3,5,6,7,8,8a-octahydroindolizine-5,7-dione [obtained as described in Preparative Example 10(iii)′ above] in 34 ml of ethanol, and the resulting mixture was left to stand for 30 minutes at room temperature. At the end of this time, the solvent and any excess pyrrolidine were distilled off under reduced pressure to afford 4.26 g (yield: 98%) of the title compound as a brown oil.

Workup

  1. customobtained
  2. waitthe resulting mixture was left
  3. distillationAt the end of this time, the solvent and any excess pyrrolidine were distilled off under reduced pressure

Sources & evidence

ORD record
ord-10ccf979cda043829237f5f534d0cc2b
Source dataset
uspto-grants-2006_10
Patent number
US07122666B2

Reaction notes

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