HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 12153759, compound → HCID 57457959, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 12153759 | HCID 12153759 | — |
| Reactant | (S)-1-Benzyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate | HCID 54190049 | — |
| Product | HCID 57457959 | HCID 57457959 | 61% |
Reaction Steps
In a similar manner to the procedures described in Preparative Examples 5(i)′ and 5(ii) above, reduction, methanesulfonylation and cyanogenation were conducted, using (S)-1-benzyloxycarbonyl-4-methylideneproline methyl ester [obtained as described in Preparative Example 8(i)′ above], instead of methyl 1-benzyloxycarbonylindoline-2-carboxylate, to give the title compound as a colorless oil (yield: 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122666B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-ff80bc77a3554abfbb9029d5b81ba0ee |
| Source note | uspto-grants-2006_10 |