(S)-1-Benzyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate → HCID 57457963, compound

HRID 1245051Notes

Reaction equation

HRID 1245051 reaction equation
CO[C:3](=O)[C@@H:4]1[CH2:8][C:7](=[CH:9][CH2:10][CH3:11])[CH2:6][N:5]1[C:12](OCC1C=CC=CC=1)=O.C[O:24][C:25](=O)[C@@H:26]1CC(=C)CN1C(OCC1C=CC=CC=1)=O>>[CH2:9]([C@@H:7]1[CH2:6][N:5]2[C@H:4]([CH2:3][C:25](=[O:24])[CH2:26][CH2:12]2)[CH2:8]1)[CH2:10][CH3:11]

Participants

3

Reactant 2

HCID 54190049(S)-1-Benzyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylateHCID 69558490HCID 69558490, compound

Product 1

HCID 57457963HCID 57457963, compoundYield 24%

Procedure

In a similar manner to the procedures described in Preparative Examples 8(ii)′, 8(iii)′, 8(iv)′, 8(v)′ and 8(vi)′ above, reactions were conducted in turn, using (S)-1-benzyloxycarbonyl-4-propylideneproline methyl ester [prepared as described in Preparative Example 25′ above] instead of (S)-1-benzyloxycarbonyl-4methylideneproline methyl ester, to give the title compound as a brown oil (yield: 24%).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-1b6aececcaa848c4904cf1cdbfaf06f3
Source dataset
uspto-grants-2006_10
Patent number
US07122666B2

Reaction notes

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