4-Chloropyridine-2-carboxylic acid → HCID 69610175, compound

HRID 1245064Notes

Reaction equation

HRID 1245064 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([OH:10])=O)[CH:3]=1.[CH3:11][O:12][C:13](=[O:29])[C@@H:14]([NH2:28])[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:18][CH:17]=1>>[CH3:11][O:12][C:13](=[O:29])[C@@H:14]([NH:28][C:8]([C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=1)=[O:10])[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 2308904-Chloropyridine-2-carboxylic acidHCID 15714801(S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate

Product 1

HCID 69610175HCID 69610175, compoundYield 85%

Procedure

3-Biphenyl-4-yl-(2S)-[(4-chloro-pyridine-2-carbonyl)-amino]-propionic acid methyl ester (1.26 g, 85%) was prepared by following general procedure A from commercially available 4-chloro picolinic acid (0.7 g, 4.4 mmol) and (2S)-amino-3-biphenyl-4-yl-propionic acid methyl ester (1.0 g, 3.9 mmol).

Sources & evidence

ORD record
ord-725a01fd0b174f32a5f19108a909d419
Source dataset
uspto-grants-2006_10
Patent number
US07122580B2

Reaction notes

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