反应详情

5-(5,6-Dimethoxy-3-methyl-1,4-benzoquinon-2-yl)methyl-2-(3-pyridyl)benzoic acid (40 mg, 0.1017 mmol) and morpholine (18 mg, 0.2608 mmol) were dissolved in methylene chloride (3 ml), then WSC-HCl (49 mg, 0.2556 mmol) was added thereto and the mixture was stirred at room temperature for 6 hours. The reaction solution was washed with water and dried and the solvent was evaporated therefrom. The residue was purified by silica gel column chromatography (methylene chloride:methanol=95:5) to give the title compound (32 mg, 0.0692 mmol, 68%).

1. washThe reaction solution was washed with water
2. customdried
3. customthe solvent was evaporated
4. customThe residue was purified by silica gel column chromatography (methylene chloride:methanol=95:5)