Cesium carbonate → HCID 21910995, compound

HRID 1245319Notes

Reaction equation

HRID 1245319 reaction equation
[CH2:1]([C:4]1[C:12]2[O:11][N:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[C:8]=2[CH:7]=[CH:6][C:5]=1[O:17][CH2:18][CH2:19][CH2:20]Br)[CH2:2][CH3:3].BrCCC[N:26]1[CH2:30][C:29](=O)[N:28]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=2)[C:27]1=[O:38].C([O-])([O-])=[O:40].[Cs+].[Cs+]>>[N:33]1[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=1[N:28]1[CH2:29][C:30](=[O:40])[N:26]([CH2:20][CH2:19][CH2:18][O:17][C:5]2[CH:6]=[CH:7][C:8]3[C:9]([C:13]([F:16])([F:15])[F:14])=[N:10][O:11][C:12]=3[C:4]=2[CH2:1][CH2:2][CH3:3])[C:27]1=[O:38]

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 12031259HCID 12031259, compoundHCID 21911034HCID 21911034, compound

Product 1

HCID 21910995HCID 21910995, compound

Procedure

A mixture of 7-propyl-3-trifluoromethyl-6-hydroxy-1,2-benzisoxazole from Example 7 (417 mg), 1-(3-bromopropyl)-3-(2-pyridyl)-imidazolidinedione (672 mg), and Cs2CO3 (867 mg) in DWF was allowed to react for 24 hours at RT. The mixture was filtered, then separated by preparative HPLC to yield the title compound as a white solid.

Workup

  1. customto react for 24 hours at RT
  2. filtrationThe mixture was filtered
  3. customseparated by preparative HPLC

Sources & evidence

ORD record
ord-4a15f484a77548d2b1631d15afc6f8b0
Source dataset
uspto-grants-2006_10
Patent number
US07125865B2

Reaction notes

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