HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → Rac-5-methyl-5-phenyl-3-(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}butyl)imidazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 5-Methyl-5-phenylhydantoin | HCID 93043 | — |
| Reactant | 7-Propyl-3-(trifluoromethyl)-6-(4-bromobutyloxy)-1,2-benzisoxazole | HCID 21910990 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Rac-5-methyl-5-phenyl-3-(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}butyl)imidazolidine-2,4-dione | HCID 21911005 | — |
Reaction Steps
rac-5-Methyl-5-phenyl-3-(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}butyl)imidazolidine-2,4-dione was prepared as for Example 10 from 5-methyl-5-phenylimidazolidine-2,4-dione and the bromide from Example 8. After aqueous work-up and silica gel chromatography (toluene: 10% acetone), the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07125865B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-133f56e7a6f745d3b4752d500d9e807c |
| Source note | uspto-grants-2006_10 |