Water → HCID 21911018, compound

HRID 1245325Notes

Reaction equation

HRID 1245325 reaction equation
[CH3:1][C:2]1([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[NH:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[CH2:15]([C:18]1[C:26]2[O:25][N:24]=[C:23]([C:27]([F:30])([F:29])[F:28])[C:22]=2[CH:21]=[CH:20][C:19]=1[O:31][CH2:32][CH2:33][CH2:34]Br)[CH2:16][CH3:17].C([O-])([O-])=O.[Cs+].[Cs+].O>CN(C=O)C>[CH3:1][C:2]1([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[NH:6][C:5](=[O:7])[N:4]([CH2:34][CH2:33][CH2:32][O:31][C:19]2[CH:20]=[CH:21][C:22]3[C:23]([C:27]([F:29])([F:30])[F:28])=[N:24][O:25][C:26]=3[C:18]=2[CH2:15][CH2:16][CH3:17])[C:3]1=[O:8]

Participants

6

Reactant 4

HCID 962WaterHCID 10796Cesium carbonateHCID 2227025-Methyl-5-(pyridin-4-yl)imidazolidine-2,4-dioneHCID 120312593-Trifluoromethyl-7-propyl-6-(3-bromopropyloxy)-benzisoxazole

Product 1

HCID 21911018HCID 21911018, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of crude rac-5-methyl-5-(4-pyridyl)-imidazolidinedione (29 mg), 7-propyl-3-trifluoromethyl-6-(3-bromopropyloxy)-1,2-benzisoxazole (27 mg) from Example 7, and Cs2CO3 (71 mg) in DMF (3.0 mL) was allowed to react overnight. Water (0.4 mL) was added and the resulting mixture separated by HPLC to yield the title compound as a clear oil.

Workup

  1. customto react overnight
  2. customthe resulting mixture separated by HPLC

Sources & evidence

ORD record
ord-3c06f20ce62741afbbaadde23c7ff512
Source dataset
uspto-grants-2006_10
Patent number
US07125865B2

Reaction notes

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