反应详情

To a solution of 6-hydroxy-7-propyl-3-(trifluoromethyl)-1,2-benzisoxazole (500 mg, 2.04 mmol) in dry CH2Cl2 was added pyridine (0.82 mL, 10.2 mmol) at 0° C. under N2. Tf2O was then added dropwise to the reaction mixture and the resulting mixture stirred for 30 min. 1N NaOH was added and the mixture extracted with CH2Cl2. Combined organic extracts were washed with brine, dried over Na2SO4 and the solvent evaporated in vacuo. The residue was purified by chromatography on silica gel using ethyl acetate and hexane (10:90) to give the title compound.

1. extractionthe mixture extracted with CH2Cl2
2. washCombined organic extracts were washed with brine
3. dry with materialdried over Na2SO4
4. customthe solvent evaporated in vacuo
5. customThe residue was purified by chromatography on silica gel