反应详情

To a solution of but-3-en-1-ol (2.39 mL, 27.73 mmol) in DMF was added imidazole (3.78 g, 55.46 mmol), and tert-butyldimethylsilyl chloride (6.3 g, 41.59 mmol). The mixture was stirred at room temperature overnight. Saturated NH4Cl was added and the mixture was extracted with ethyl acetate three times. Combined organic extracts were washed twice with water and brine then dried over Na2SO4. The solvent was evaporated in vacuo to give title compound.

1. extractionthe mixture was extracted with ethyl acetate three times
2. washCombined organic extracts were washed twice with water and brine
3. dry with materialthen dried over Na2SO4
4. customThe solvent was evaporated in vacuo