Dihydrouracil → HCID 21910982, compound

HRID 1245351Notes

Reaction equation

HRID 1245351 reaction equation
N1CCC(=O)NC1=O.[CH3:9][C:10]1(C2C=CC=CC=2)[NH:14][C:13](=[O:15])[N:12]([CH2:16][CH2:17][CH2:18][O:19][C:20]2[CH:34]=[CH:33][C:23]3[C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[N:25][O:26][C:22]=3[C:21]=2[CH2:35][CH2:36][CH3:37])[C:11]1=[O:38]>>[CH2:35]([C:21]1[C:22]2[O:26][N:25]=[C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:23]=2[CH:33]=[CH:34][C:20]=1[O:19][CH2:18][CH2:17][CH2:16][N:12]1[C:11](=[O:38])[CH2:10][CH2:9][NH:14][C:13]1=[O:15])[CH2:36][CH3:37]

Participants

3

Reactant 2

HCID 649DihydrouracilHCID 21910997Rac-5-methyl-5-phenyl-3-(3-{[7-propyl-3-(phenyl)-1,2-benzisoxazol-6-yl]oxy}propyl)imidazolidine-2,4-dione

Product 1

HCID 21910982HCID 21910982, compound

Procedure

3-(3-{[7-Propyl-3-(phenyl)-1,2-benzisoxazol-6-yl]oxy}propyl)dihydropyrimidine-2,4(1H,3H)-dione was prepared as for Example 10 from dihydropyrimidine-2,4(1H,3H)-dione and the bromide from Example 27. After aqueous work-up and silica gel chromatography, the title compound was obtained.

Sources & evidence

ORD record
ord-5ef6a4c1ea114b8f8404c2d10eb3660c
Source dataset
uspto-grants-2006_10
Patent number
US07125865B2

Reaction notes

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