Dihydrouracil → 3-(3-{[7-Propyl-3-(phenyl)-1,2-benzisoxazol-6-yl]oxy}propyl)-dihydropyrimidine-2,4(1h,3h)-dione

Participants

Role	Name	HCID	Charge
Reactant	Dihydrouracil	HCID 649	—
Reactant	Rac-5-methyl-5-phenyl-3-(3-{[7-propyl-3-(phenyl)-1,2-benzisoxazol-6-yl]oxy}propyl)imidazolidine-2,4-dione	HCID 21910997	—
Product	3-(3-{[7-Propyl-3-(phenyl)-1,2-benzisoxazol-6-yl]oxy}propyl)-dihydropyrimidine-2,4(1h,3h)-dione	HCID 21910982	—

Reaction Steps

3-(3-{[7-Propyl-3-(phenyl)-1,2-benzisoxazol-6-yl]oxy}propyl)dihydropyrimidine-2,4(1H,3H)-dione was prepared as for Example 10 from dihydropyrimidine-2,4(1H,3H)-dione and the bromide from Example 27. After aqueous work-up and silica gel chromatography, the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07125865B2
Source dataset	uspto-grants-2006_10
ORD ID	ord-5ef6a4c1ea114b8f8404c2d10eb3660c
Source note	uspto-grants-2006_10