Dihydro-6-methyl-2,4(1H,3H)-pyrimidinedione → HCID 21911012, compound

HRID 1245352Notes

Reaction equation

HRID 1245352 reaction equation
[CH3:1][CH:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH2:3]1.[CH2:10]([C:13]1[C:21]2[O:20][N:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[C:17]=2[CH:16]=[CH:15][C:14]=1[O:26][CH2:27][CH2:28][CH2:29]Br)[CH2:11][CH3:12]>>[CH3:1][CH:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:29][CH2:28][CH2:27][O:26][C:14]2[CH:15]=[CH:16][C:17]3[C:18]([C:22]([F:24])([F:25])[F:23])=[N:19][O:20][C:21]=3[C:13]=2[CH2:10][CH2:11][CH3:12])[C:4](=[O:9])[CH2:3]1

Participants

3

Reactant 2

HCID 97818Dihydro-6-methyl-2,4(1H,3H)-pyrimidinedioneHCID 12031259HCID 12031259, compound

Product 1

HCID 21911012HCID 21911012, compound

Procedure

6-Methyl-3-(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)dihydropyrimidine-2,4(1H,3H)-dione was prepared as for Example 10 from 6-methyldihydropyrimidine-2,4(1H,3H)-dione and the bromide from Example 7. After aqueous work-up and silica gel chromatography, the title compound was obtained.

Sources & evidence

ORD record
ord-dd6f558d00954e1ca7d495c5d6f688a1
Source dataset
uspto-grants-2006_10
Patent number
US07125865B2

Reaction notes

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