HCID 59913127, compound → HCID 86592944, compound

HRID 1245387Notes

Reaction equation

HRID 1245387 reaction equation
[CH2:1]([O:5][C:6](=[O:12])[CH2:7][C:8]([CH2:10][OH:11])=[CH2:9])[CH2:2][CH2:3][CH3:4].[CH3:13][C:14]1[CH:23]=[C:22]([CH2:24][O:25][C:26]2[CH:34]=[CH:33][C:29]([CH:30]=[N:31][OH:32])=[CH:28][CH:27]=2)[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=1>>[CH2:1]([O:5][C:6](=[O:12])[CH2:7][C:8]1([CH:10]=[O:11])[O:32][N:31]=[C:30]([C:29]2[CH:28]=[CH:27][C:26]([O:25][CH2:24][C:22]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[N:15]=[C:14]([CH3:13])[CH:23]=3)=[CH:34][CH:33]=2)[CH2:9]1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 59913127HCID 59913127, compoundHCID 738530794-(2-Methyl-quinolin-4-ylmethoxy)-benzaldehyde oxime

Product 1

HCID 86592944HCID 86592944, compoundYield 36%

Procedure

Following a procedure analogous to that used in step 1c, but using 3-hydroxymethyl-but-3-enoic acid butyl ester from step 3a and 4-(2-methyl-quinolin-4-ylmethoxy)-benzaldehyde oxime from step 1b, the crude product was prepared. The product was purified by FCC on silica gel to give {5-formyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-acetic acid butyl ester (0.13 g, 36%) as an oil. MS found: (M+H)+=461.

Workup

  1. customthe crude product was prepared
  2. customThe product was purified by FCC on silica gel

Sources & evidence

ORD record
ord-01a9a6a4b4ac4c3991905d5b219978af
Source dataset
uspto-grants-2006_10
Patent number
US07125870B2

Reaction notes

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