反应详情

HCl (g) was bubbled through a solution of the product from step 10d (0.3 g, 0.65 mmol) in methanol (20 mL) at room temperature for 5 minutes and the reaction was stirred for 3 h. This was complete, concentrated in vacuo to give a solid which was triturated into a powder with ethyl ether to give 3-amino-3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester di-hydrochloride salt (0.21 g, 64%) as a off white solid. MS found: (M+H)+=420.

1. concentrationThis was complete, concentrated in vacuo
2. customto give a solid which
3. customwas triturated into a powder with ethyl ether