HRID1245405

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)C=CC1(C(C)(C)O[SiH2]C(C)(C)C)CC(c2ccc(OCc3cc(C)nc4ccccc34)cc2)=NO1

HCID131725998

未命名化合物

PRODUCTS

生成物

HCID131725999

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

The product from step 24d (0.24 g, 0.44 mmol) was dissolved in methanol (15 mL), degassed by bubbling nitrogen through the solution, charged with Rh/C and hydrogen gas (40 PSI), and shaken for 2 h. The reaction was filtered and concentrated to give 3-{5-(tert-butyl-dimethyl-silanyloxymethyl)-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester as a crude oil. MS found: (M+H)+=549.

WORKUP

后处理

customdegassed
customby bubbling nitrogen through the solution
additioncharged with Rh/C and hydrogen gas (40 PSI)
filtrationThe reaction was filtered
concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-66efaaec73ae4ee19f27db11eff66381
来源数据集: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07125870B2
来源说明: uspto-grants-2006_10

反应 SMILES

[CH3:1][O:2][C:3](=[O:39])[CH:4]=[CH:5][C:6]1([C:30]([CH3:38])([CH3:37])[O:31][SiH2:32][C:33]([CH3:36])([CH3:35])[CH3:34])[O:10][N:9]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:22]=[C:21]([CH3:29])[CH:20]=3)=[CH:13][CH:12]=2)[CH2:7]1>CO>[CH3:1][O:2][C:3](=[O:39])[CH2:4][CH2:5][C:6]1([C:30]([CH3:38])([CH3:37])[O:31][SiH2:32][C:33]([CH3:35])([CH3:34])[CH3:36])[O:10][N:9]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:22]=[C:21]([CH3:29])[CH:20]=3)=[CH:13][CH:12]=2)[CH2:7]1