methyl 3-[5-(2-tert-butylsilyloxypropan-2-yl)-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-4H-1,2-oxazol-5-yl]prop-2-enoate → methyl 3-[5-(2-tert-butylsilyloxypropan-2-yl)-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-4H-1,2-oxazol-5-yl]propanoate

Participants

Reaction Steps

The product from step 24d (0.24 g, 0.44 mmol) was dissolved in methanol (15 mL), degassed by bubbling nitrogen through the solution, charged with Rh/C and hydrogen gas (40 PSI), and shaken for 2 h. The reaction was filtered and concentrated to give 3-{5-(tert-butyl-dimethyl-silanyloxymethyl)-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-propionic acid methyl ester as a crude oil. MS found: (M+H)+=549.

Provenance & Evidence