4-Chloroaniline → HCID 21912477, compound

HRID 1245415Notes

Reaction equation

HRID 1245415 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[F:9][C:10]1[N:15]=[C:14](F)[CH:13]=[C:12]([F:17])[N:11]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C.O>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:14]2[CH:13]=[C:12]([F:17])[N:11]=[C:10]([F:9])[N:15]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 78124-ChloroanilineHCID 11430Potassium CarbonateHCID 696772,4,6-Trifluoropyrimidine

Product 1

HCID 21912477HCID 21912477, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

4-Chloroaniline was added to a stirred solution of 2,4,6-trifluoropyrimidine (7.7 g), potassium carbonate (7.86 g) in ethanol (80 ml). The mixture was stirred at room temperature for 16 h, diluted with water, extracted with ethyl acetate, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/ethyl acetate (4:1). Yield 8.3 g cream solid

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure
  4. customThe residue was purified by chromatography on silica eluting with isohexane/ethyl acetate (4:1)

Sources & evidence

ORD record
ord-1ac2755869db4e428904c9420e263bae
Source dataset
uspto-grants-2006_10
Patent number
US07125881B2

Reaction notes

Loading…