Morpholine → HCID 9973027, compound

HRID 1245417Notes

Reaction equation

HRID 1245417 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]2[CH:20]=[C:19](F)[N:18]=[C:17]([C:22]#[N:23])[N:16]=2)=[CH:10][CH:9]=1>C(O)(C)C>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([NH:14][C:15]2[CH:20]=[C:19]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)[N:18]=[C:17]([C:22]#[N:23])[N:16]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 21912474HCID 21912474, compound

Product 1

HCID 9973027HCID 9973027, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Morpholine (0.16 g) was added to a solution of the product from step (ii) (0.16 g) in iso-propylalcohol (4 ml) and stirred for 2 h at room temperature. The mixture was partitioned between ethyl acetate and aqueous sodium hydrogencarbonate solution, the organics separated, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/ethyl acetate (1:1). Yield 0.09 g

Workup

  1. customThe mixture was partitioned between ethyl acetate and aqueous sodium hydrogencarbonate solution
  2. dry with materialthe organics separated, dried (MgSO4)
  3. customevaporated under reduced pressure
  4. customThe residue was purified by chromatography on silica eluting with isohexane/ethyl acetate (1:1)

Sources & evidence

ORD record
ord-478c587d02a648faa862bd5736563c11
Source dataset
uspto-grants-2006_10
Patent number
US07125881B2

Reaction notes

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