Morpholine → HCID 21912455, compound

HRID 1245418Notes

Reaction equation

HRID 1245418 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[C:9]([F:16])=[N:10][C:11]([F:15])=[N:12][C:13]=1F.C(N(CC)C(C)C)(C)C>O1CCOCC1>[Cl:7][C:8]1[C:13]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[N:12][C:11]([F:15])=[N:10][C:9]=1[F:16]

Participants

5

Reactant 3

HCID 8083MorpholineHCID 69679Pyrimidine, 5-chloro-2,4,6-trifluoro-HCID 81531Diisopropylethylamine

Product 1

HCID 21912455HCID 21912455, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Morpholine (0.774 mg) was added to a solution of 5-chloro-2,4,6-trifluoropyrimidine (1.5 g), N,N-diisopropylethylamine (1.15 g) in 1,4-dioxane (30 ml) and stirred at room temperature for 16 h. The mixture was partitioned between ethyl acetate and water, the organic layer dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 8% ethyl acetate in isohexane. Yield 0.88 g

Workup

  1. customThe mixture was partitioned between ethyl acetate and water
  2. dry with materialthe organic layer dried (MgSO4)
  3. customevaporated under reduced pressure
  4. customThe residue was purified by chromatography on silica eluting with 8% ethyl acetate in isohexane

Sources & evidence

ORD record
ord-5714b6dcb91a4d8594eae8c3cece52d6
Source dataset
uspto-grants-2006_10
Patent number
US07125881B2

Reaction notes

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