Iodoethane → 2-(Ethylthio)-5-methoxypyrimidine-4,6(1H,5H)-dione

HRID 1245422Notes

Reaction equation

HRID 1245422 reaction equation
[CH2:1](I)[CH3:2].[CH3:4][O:5][CH:6]1[C:11](=[O:12])[NH:10][C:9](=[S:13])[NH:8][C:7]1=[O:14].[OH-].[Na+]>O>[CH2:1]([S:13][C:9]1[NH:8][C:7](=[O:14])[CH:6]([O:5][CH3:4])[C:11](=[O:12])[N:10]=1)[CH3:2]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 14798Sodium HydroxideHCID 219124765-Methoxy-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Product 1

HCID 219124642-(Ethylthio)-5-methoxypyrimidine-4,6(1H,5H)-dione

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl iodide (11.2 ml) was added dropwise to a stirred mixture of the product from step (i) (23 g) and sodium hydroxide (6 g) in water (400 ml). After 16 h the mixture was filtered, the filtrate acidified to pH1 and the precipitate filtered, washed with water and dried. Yield 17.8 g

Workup

  1. filtrationAfter 16 h the mixture was filtered
  2. filtrationthe precipitate filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-7e54e2529ee5435eba8ed70b5e3726f1
Source dataset
uspto-grants-2006_10
Patent number
US07125881B2

Reaction notes

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