HCID 21912466, compound → HCID 10088052, compound

HRID 1245425Notes

Reaction equation

HRID 1245425 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:14]([N+:15]([O-])=O)=[C:13]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[N:12]=[C:11]([C:24]#[N:25])[N:10]=2)=[CH:4][CH:3]=1>[Pd].C(OCC)(=O)C>[NH2:15][C:14]1[C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[N:10][C:11]([C:24]#[N:25])=[N:12][C:13]=1[N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1

Participants

4

Reactant 1

HCID 21912466HCID 21912466, compound

Product 1

HCID 10088052HCID 10088052, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The product from step (ii) (1.7 g) and 10% palladium on charcoal (0.2 g) in ethyl acetate (300 ml) was hydrogenated at 2 Bar for 8 h, filtered through celite and the solvent evaporated under reduced pressure. Yield 1.05 g

Workup

  1. filtrationfiltered through celite
  2. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-f096fc8031294e69ab79b2e932ad3cd8
Source dataset
uspto-grants-2006_10
Patent number
US07125881B2

Reaction notes

Loading…