Benzylurea → HCID 21912490, compound

HRID 1245445Notes

Reaction equation

HRID 1245445 reaction equation
[CH2:1]([NH:8][C:9]([NH2:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.CO.[Pd]>[NH2:8][CH2:1][CH:2]1[CH2:7][CH2:6][N:11]([C:9]([NH:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:10])[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 10853Benzylurea

Product 1

HCID 21912490HCID 21912490, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

) 4 g of benzylurea 14a were dissolved in a mixture of ethyl acetate/CH3OH 3:1 with heating and, after addition of 0.2 g of 10% Pd on activated carbon, hydrogenated under standard conditions at 35 to 40° C. After the reaction was complete, the mixture was filtered through Celite and evaporated. 2.8 g; ESI-MS [M+H+]=248.15

Workup

  1. temperaturewith heating
  2. customhydrogenated under standard conditions at 35 to 40° C
  3. filtrationthe mixture was filtered through Celite
  4. customevaporated

Sources & evidence

ORD record
ord-0e4cf875518540669772ea0743a6916d
Source dataset
uspto-grants-2006_10
Patent number
US07125883B1

Reaction notes

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