Hydrochloric Acid → HCID 131723149, compound

HRID 1245579Notes

Reaction equation

HRID 1245579 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][CH3:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([CH2:21][CH3:22])=[N:17]1)[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21912727HCID 21912727, compound

Product 1

HCID 131723149HCID 131723149, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1-(tert-butoxycarbonyl)-4-(1,3-diethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (348 mg) (from Step E) in 2.5 N HCl in methanol was stirred at rt for 16 h. The solution was concentrated and the resulting solid was suspended in ethyl acetate, filtered and dried to afford the title compound.

Workup

  1. concentrationThe solution was concentrated
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-e86fe8f6a67f46659527905dc36418a0
Source dataset
uspto-grants-2006_10
Patent number
US07125887B2

Reaction notes

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