Piperidine → HCID 21912775, compound

HRID 1245613Notes

Reaction equation

HRID 1245613 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][O:22][CH3:23])[C:15]=2[CH3:24])[CH2:10][CH2:9]1)=O)(C)(C)C.N1CCCCC1>>[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:24])[C:16]([CH2:21][O:22][CH3:23])=[N:17]1)[CH3:20]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 21912762HCID 21912762, compound

Product 1

HCID 21912775HCID 21912775, compound

Procedure

The title compound was prepared from 1-(tert-butoxycarbonyl)-4-(1-ethyl-3-methoxymethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (from Step A) using a procedure analogous to that described for Piperidine 8, Step F. 1H-NMR (500 MHz) δ 1.36 (t, J=7.2, 3H), 1.71–1.74 (m, 2H), 1.97–2.09 (m, 2H), 2.11 (s, 3H), 2.72–2.80 (m, 3H), 3.25–3.35 (m, 2H), 3.37 (s, 3H), 4.11 (q, J=7.2, 2H), 4.37 (s, 2H).

Sources & evidence

ORD record
ord-bdb10a67c4684789a54cf0050433c79c
Source dataset
uspto-grants-2006_10
Patent number
US07125887B2

Reaction notes

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