2-Amino-4-methylthiazole → HCID 9879480, compound

HRID 1245630Notes

Reaction equation

HRID 1245630 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH3:7])[N:6]=1.[Cl:8][C:9]1[C:10]([CH3:19])=[C:11]([S:15](Cl)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1>>[Cl:8][C:9]1[C:10]([CH3:19])=[C:11]([S:15]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH3:7])[N:6]=2)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 741432-Amino-4-methylthiazoleHCID 5227343-Chloro-2-methylbenzenesulfonyl chloride

Product 1

HCID 9879480HCID 9879480, compound

Procedure

The title compound was prepared from 2-amino-4-methylthiazole (285 mg) and 3-chloro-2-methylbenzenesulfonyl chloride (619 mg) according to METHOD A. This afforded 167 mg (22%) of a yellow solid after purification: 1H NMR (DMSO-4) δ 2.1 (s, 3H), 2.6 (s, 3H), 6.35 (s, 1H), 7.35 (t, 1H), 7.65 (d, 1H), 7.85 (d, 1H), 12.7 (br s, 1H).

Workup

  1. customThis afforded 167 mg (22%) of a yellow solid after purification

Sources & evidence

ORD record
ord-480e05efe36c4081ab985267445e0fb0
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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