3-Chloro-2-methylbenzenesulfonyl chloride → 3-Chloro-N-(4-ethyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide

HRID 1245635Notes

Reaction equation

HRID 1245635 reaction equation
[CH2:1]([C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1)[CH3:2].[Cl:9][C:10]1[C:11]([CH3:20])=[C:12]([S:16](Cl)(=[O:18])=[O:17])[CH:13]=[CH:14][CH:15]=1>>[Cl:9][C:10]1[C:11]([CH3:20])=[C:12]([S:16]([NH:8][C:5]2[S:6][CH:7]=[C:3]([CH2:1][CH3:2])[N:4]=2)(=[O:18])=[O:17])[CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 123782054-Ethyl-1,3-thiazol-2-amine

Product 1

HCID 98799793-Chloro-N-(4-ethyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamideYield 17%

Procedure

The title compound was prepared from 4-ethyl-1,3-thiazol-2-ylamine (METHOD H) and 3-chloro-2-methylbenzenesulfonyl chloride according to METHOD A, yellowish solid, 53 mg (17% yield): HRMS Calcd (found) for C12H13ClN2O2S2 m/z 316.0107 (316.0120).

Sources & evidence

ORD record
ord-78aa7a900dd542d88c4f608993ebed80
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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