3-Chloro-2-methylbenzenesulfonyl chloride → HCID 10269059, compound

HRID 1245641Notes

Reaction equation

HRID 1245641 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([NH2:10])[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:11][C:12]1[C:13]([CH3:22])=[C:14]([S:18](Cl)(=[O:20])=[O:19])[CH:15]=[CH:16][CH:17]=1>>[C:1]([C:5]1[N:6]=[C:7]([NH:10][S:18]([C:14]2[CH:15]=[CH:16][CH:17]=[C:12]([Cl:11])[C:13]=2[CH3:22])(=[O:19])=[O:20])[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 27342024-tert-Butyl-1,3-thiazol-2-amine

Product 1

HCID 10269059HCID 10269059, compoundYield 40%

Procedure

The title compound was prepared from 4-tert-butyl-1,3-thiazol-2-ylamine (METHOD H) and 3-chloro-2-methylbenzenesulfonyl chloride according to METHOD A, white foam, 273 mg (40% yield). mp 178° C.; HRMS Calcd (found) for C14H17ClN2O2S2 m/z 344.0420 (344.0408).

Sources & evidence

ORD record
ord-5496c0b9d1ff45ac9a91e2d3af8efcfd
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

Loading…