4-Chlorobenzenesulfonyl chloride → N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-chlorobenzenesulfonamide

HRID 1245645Notes

Reaction equation

HRID 1245645 reaction equation
[C:1]([C:4]1[S:8][C:7]([NH2:9])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1>>[C:1]([C:4]1[S:8][C:7]([NH:9][S:18]([C:15]2[CH:16]=[CH:17][C:12]([Cl:11])=[CH:13][CH:14]=2)(=[O:20])=[O:19])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 7208825-Acetyl-2-amino-4-methylthiazole

Product 1

HCID 11163340N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-chlorobenzenesulfonamide

Procedure

The title compound was prepared from 5-acetyl-2-amino-4-methylthiazole and 4-chlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (12.2 mg) with purity >90%. LCMS (pos) m/z 331.2.

Sources & evidence

ORD record
ord-704ed33f3c1d41f5adb539d08d6d101e
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

Loading…