5-Acetyl-2-amino-4-methylthiazole → N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-propylbenzenesulfonamide

HRID 1245648Notes

Reaction equation

HRID 1245648 reaction equation
[C:1]([C:4]1[S:8][C:7]([NH2:9])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[CH2:11]([C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1)[CH2:12][CH3:13]>>[C:1]([C:4]1[S:8][C:7]([NH:9][S:20]([C:17]2[CH:18]=[CH:19][C:14]([CH2:11][CH2:12][CH3:13])=[CH:15][CH:16]=2)(=[O:22])=[O:21])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 7208825-Acetyl-2-amino-4-methylthiazoleHCID 27372224-N-Propylbenzenesulphonyl chloride

Product 1

HCID 11209950N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-propylbenzenesulfonamide

Procedure

The title compound was prepared from 5-acetyl-2-amino-4-methylthiazole and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (11.6 mg) with purity >90%: MS (pos) m/z 339.2; HEMS m/z 338.0748 (calc. of monoisotopic mass for C15H18N2O3S2 gives 338.0759).

Sources & evidence

ORD record
ord-ffd26df12b0e45868fb94858c4f84bf9
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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