4-Bromo-2,5-difluorobenzenesulfonyl Chloride → HCID 11200726, compound

HRID 1245653Notes

Reaction equation

HRID 1245653 reaction equation
[C:1]([C:4]1[S:8][C:7]([NH2:9])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[Br:11][C:12]1[C:17]([F:18])=[CH:16][C:15]([S:19](Cl)(=[O:21])=[O:20])=[C:14]([F:23])[CH:13]=1>>[C:1]([C:4]1[S:8][C:7]([NH:9][S:19]([C:15]2[CH:16]=[C:17]([F:18])[C:12]([Br:11])=[CH:13][C:14]=2[F:23])(=[O:21])=[O:20])=[N:6][C:5]=1[CH3:10])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 5745904-Bromo-2,5-difluorobenzenesulfonyl ChlorideHCID 7208825-Acetyl-2-amino-4-methylthiazole

Product 1

HCID 11200726HCID 11200726, compound

Procedure

The title compound was prepared from 5-acetyl-2-amino-4-methylthiazole (42 mg) and 4-bromo-2,5-difluorobenzenesulfonyl chloride (79 mg) as described in the synthetic METHOD B to give a white solid (21.0 mg) with purty >90%: MS (pos) m/z 411.2, 413.2.

Sources & evidence

ORD record
ord-998a0c4ca70143438884655d563ed6c4
Source dataset
uspto-grants-2006_10
Patent number
US07125900B2

Reaction notes

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